The Journal of Biological Chemistry
نویسنده
چکیده
Human serum albumin (HSA) has been allowed to react with varying amounts of iodine under mild conditions. Almost all of the tyrosyl residues of HSA may be converted to iodotyrosyl residues (primarily diiodotyrosyl) without producing significant changes in the conformation of the protein. Difference spectral measurements in urea show the disappearance of “burled” tyrosyl and the appearance of “buried” diiodotyrosyl residues; a difference spectral peak attributed to diiodotyrosyl residues in iodinated HSA is seen at 302 mp. It is proposed that the partly nonaqueous environment of “buried” tyrosyl residues directs their preferential conversion to diiodotyrosyl residues.
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